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high doses of vitamins B6, B12 and folic acid reduces the removal of the brain of a 30% two-year course of study

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Aa high doses of B vitamins may delay cognitive decline in older people which is the precursor of dementia such as Alzheimer's disease, according to a study.

Speaking at the British Science Festival Bradford on Tuesday, Celeste de Jager, a neuropsychologist at the University of Oxford, said that taking vitamins B6, B12 and folic acid Medicinal quantities reduces the overall contraction of the brain of a person 30% during the two-year study.

Their work, published recently in the International Journal of Geriatric Psychiatry, was conducted in 270 men and women over 70 who had mild cognitive impairment (MCI), a condition that affects six elderly and can interfere with memory, language and other mental functions. About half of people with MCI will develop Alzheimer's disease within five years after initial diagnosis.

Taking B vitamins and folic acid is known to control levels of an amino acid called homocysteine ??in the blood. High levels of this chemical can damage blood vessels and are associated with an increased risk of dementia.

"Homocysteine ??is a known risk factor for cognitive decline in older people's disease and Alzheimer's disease and other types of dementia such as vascular dementia," said De Jager. "It may be injurious to the endothelial layer of blood cells. Also binds to receptors in the brain that is found in neurons and appears to contribute to the atrophy is associated with Alzheimer's disease. "

the whole group, de Jager has found that people who take vitamins have been a decrease of 30% reduction in brain tissue from more than two years, compared with placebo. In individuals with the highest levels of homocysteine ??in the blood at the beginning of the experiment, however, vitamins more profitable, reducing brain shrinkage by 50% in these cases.

Rebecca Wood, chief executive of the UK Alzheimer's Research, which co-funded the study, said the results were encouraging for the use of B vitamins, but larger studies would be needed to find out how this could have a protective effect against mental decline of older people. "People should talk to your doctor before starting a vitamin regime. Monitoring of clinical trials should have a particular focus on whether the B vitamins could prevent the conversion of MCI to Alzheimer's disease. "

De Jager is already planning to extend their study of over 1000 people. "It will be more than two years and clinical and cognitive outcomes are the main results in this time instead of brain atrophy."

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